Wednesday, September 28, 2016

Osteoimmunological Aspects of Biomechanics

Reported by : Aviral Vatsa

Biomechanics is increasingly becoming the vital link between various biological modulations and physiological processes. Its quantification and 'predictable' nature makes biomechanical approach even more appealing.

Authours
  • Katharina Kerschan-Schindl 
  • Gerold Ebenbichler

Abstract

Different endogenous and exogenous factors which interfere with bone health have been identified. Among these, physical activity that relates to regular intermittent mechanical bone loading seems to be one of the major factors controlling bone mass and the prevention of osteoporotic fractures. Moreover, an interaction between bone homeostasis and the immune system which may be modified by regular physical activity exists. Bone and immune cells share a common site of origin, the bone marrow. They are supposed to influence each other not only during maturation; osteoclasts and immune cells have a number of regulatory molecules in common including cytokines, receptors, signalling molecules, and transcription factors, which influence each other.

Chapter
pp 109-124 Date: 
DOI 10.1007/978-3-319-34238-2_5

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